NDLI: Tumoral acidic extracellular pH targeting of pH-responsive MPEG-poly(beta-amino ester) block copolymer micelles for cancer therapy.

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Tumoral acidic extracellular pH targeting of pH-responsive MPEG-poly(beta-amino ester) block copolymer micelles for cancer therapy.

Content Provider	Semantic Scholar
Author	Ko, Jinyoung Park, Kyeongsoon Kim, Yoo-Shin Kim, Min Sang Han, Jong Kwon Kim, Kwangmeyung Park, Rang-Woon Song, Hyun Kyu Lee, Doo Sung Kwon, Ick Chan
Copyright Year	2007
Abstract	The main objective of this study was to develop and characterize a pH-responsive and biodegradable polymeric micelle as a tumor-targeting drug delivery system. The pH-responsive block copolymer was synthesized by a Michael-type step polymerization of hydrophilic methyl ether poly(ethylene glycol) (MPEG) and pH-responsive and biodegradable poly(beta-amino ester), resulting in an amphiphilic MPEG-poly(beta-amino ester) block copolymer. This copolymer, which formed nano-sized self-assembled micelles under aqueous conditions, could be efficiently (74.5%) loaded with doxorubicin (DOX) using a solvent evaporation method. In an in vitro drug release study, these DOX-loaded polymeric micelles showed noticeable pH-dependent micellization-demicellization behavior, with rapid release of DOX from the micelles in weakly acidic environments (pH 6.4) but very slow release under physiological conditions (pH 7.4). Moreover, due to demicellization, the tumor cell uptake of DOX released from polymeric micelles was much higher at pH 6.4 than at pH 7.4. When in vivo anti-tumor activity of pH-responsive polymeric micelles was evaluated by injecting the DOX-loaded polymeric micelles into B16F10 tumor-bearing mice, these micelles notably suppressed tumor growth and also prolonged survival of the tumor-bearing mice, compared with mice treated with free DOX.
File Format	PDF HTM / HTML
DOI	10.1016/j.jconrel.2007.07.012
PubMed reference number	17894942
Journal	Medline
Volume Number	123
Issue Number	2
Alternate Webpage(s)	http://song.korea.ac.kr/assets/pdf/jko-pH-jcr.pdf
Alternate Webpage(s)	https://doi.org/10.1016/j.jconrel.2007.07.012
Journal	Journal of controlled release : official journal of the Controlled Release Society
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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