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Is low birth weight a risk indicator for congenital cytomegalovirus infection?
| Content Provider | Semantic Scholar |
|---|---|
| Author | Al-Hareth, Zakyieh Monem, Fawza Mohammad Sharif Megiud, Nagwa Abdel |
| Copyright Year | 2009 |
| Abstract | BACKGROUND Congenital cytomegalovirus infection is currently the leading cause of congenital infection in 0.2-2.2% of live births worldwide leading to variable serious sequalae. The aim of the study was to determine if low birth weight is an indicator of CMV congenital infection evidenced by detecting CMV-DNA in umbilical cord blood at the time of delivery. METHODOLOGY CMV-IgG and IgM antibodies and CMV-DNAemia were assessed in umbilical cord blood of two hundreds newborns, one hundred of whom had birth weight < or = 2700 gram and/or head circumference < or = 32 cm. RESULTS CMV-IgM was not detected, while CMV-IgG was positive in 80-90% of the two hundreds tested newborns. CMV-DNA was detected in four out of the 200 newborns. One of them was over the adopted weight limit (> 2700 gram). CONCLUSIONS CMV-IgM and IgG antibodies assessment was not a potential discriminative test to identify congenitally infected newborns. In addition, low birth weight and small head circumference at birth failed to predict congenital CMV infection. CMV-DNA detection in umbilical cord blood at the time of delivery using real-time PCR of all newborns is recommended as decisive, rapid and non-invasive test. |
| Starting Page | 87 |
| Ending Page | 108 |
| Page Count | 22 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://jidc.org/index.php/journal/article/download/20130378/339/ |
| PubMed reference number | 20130378v1 |
| Volume Number | 4 |
| Issue Number | 1 |
| Journal | Journal of infection in developing countries |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Arabic numeral 100 Cytomegalovirus Infections Eighty Entity Name Part Qualifier - adopted Head circumference Hip Dislocation, Congenital Infant, Newborn Low Birth Weight Infant Toxoplasmosis, Congenital Umbilical Cord Blood Umbilicus (Anatomy) congenital cytomegalovirus gram |
| Content Type | Text |
| Resource Type | Article |
