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Diastereoselective synthesis of 1,1,4-trisubstituted-2,3,4,9-tetrahydrospiro-β-carbolines via glacial acetic acid catalyzed Pictet - Spengler reaction
| Content Provider | Semantic Scholar |
|---|---|
| Author | Shumaila, Abdullah Mabkhot Ali Puranik, Vedavati G. Kusurkar, Radhika S. |
| Copyright Year | 2010 |
| Abstract | The Pictet-Spengler reaction of substituted tryptamines with cyclic ketones using glacial acetic acid afforded only one diastereomer of unreported 1,1,4-trisubstituted-2,3,4,9-tetrahydrospiro-βcarbolines. The stereoselectivity in the reaction has been demonstrated using unsymmetrical ketones and single- crystal X-ray analysis of one of the spiro products in the form of base, its sulfate and hydrochloride salts, which indicated the formation of only the R,R diastereomer. |
| File Format | PDF HTM / HTML |
| DOI | 10.3998/ark.5550190.0012.204 |
| Volume Number | 2011 |
| Alternate Webpage(s) | http://www.arkat-usa.org/get-file/37100/ |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |