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Meta-analysis of GSTM1 null genotype and lung cancer risk in Asians
| Content Provider | Semantic Scholar |
|---|---|
| Author | Liu, Xiaomin Li, Zhijuan Zhang, Zhiye Zhang, Weimin Li, Wei Xiao, Zhongyue Liu, Huazhuan Jiao, Hongduo Wang, Yi Li, Guoguo |
| Copyright Year | 2014 |
| Abstract | BACKGROUND Several molecular epidemiological studies have been conducted to examine the association between glutathione S-transferase M 1 (GSTM1) null genotype and lung cancer in Asians; however, the conclusions remained controversial. We therefore performed an extensive meta-analysis on 31 published case-control studies with a total of 5347 lung cancer cases and 6072 controls. MATERIAL/METHODS PubMed and EMBASE were searched to identify case-control studies investigating the associations of GSTM1 null genotype with risk of lung cancer in Asians. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of association between lung cancer risk and polymorphism of GSTM1. RESULTS GSTM1 null genotype was significantly associated with lung cancer risk (OR=1.43; 95% CI, 1.30-1.58). This result remained statistically significant when the adjusted ORs were combined (OR=1.38; 95% CI, 1.23-1.54). In the subgroup analysis by sex, there were significant associations in women and men. When stratifying for histology, this genotype showed increased adenocarcinoma risk and squamous cell carcinoma risk. In the subgroup analysis stratified by smoking status, lung cancer risk was increased in both smokers and non-smokers. CONCLUSIONS This study suggests that GSTM1 null genotype is a risk factor for lung cancer in Asians. |
| Starting Page | 1239 |
| Ending Page | 1245 |
| Page Count | 7 |
| File Format | PDF HTM / HTML |
| PubMed reference number | 25033877 |
| Alternate Webpage(s) | https://doi.org/10.12659/MSM.890490 |
| DOI | 10.12659/msm.890490 |
| Journal | Medical science monitor : international medical journal of experimental and clinical research |
| Volume Number | 20 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Abstract Summary Adenocarcinoma Carcinoma of lung Confidence Intervals Epidemiology Estimated GSTM1 gene GSTM1 protein, human Glutathione S-Transferase Index Journal Lithium Local Area Networks Materia Medica Mental association Null Value Odds Ratio Pseudo brand of pseudoephedrine Scientific Publication Squamous Epithelial Cells Squamous cell carcinoma Status Epilepticus Subgroup A Nepoviruses Transferase |
| Content Type | Text |
| Resource Type | Article |
