NDLI: A series of Zn(ii) terpyridine complexes with enhanced two-photon-excited fluorescence for in vitro and in vivo bioimaging.

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A series of Zn(ii) terpyridine complexes with enhanced two-photon-excited fluorescence for in vitro and in vivo bioimaging.

Content Provider	Semantic Scholar
Author	Zhang, Qiong Tian, Xiaohe Hu, Zhangjun Brommesson, Caroline Wu, Jieying Zhou, Hongping Li, Shengli Yang, Jiaxiang Sun, Zhaoqi Tian, Yupeng Uvdal, Kajsa
Copyright Year	2015
Abstract	It is still a challenge to obtain two-photon excited fluorescent bioimaging probes with intense emission, high photo-stability and low cytotoxicity. In the present work, four Zn(ii)-coordinated complexes (1-4) constructed from two novel D-A and D-π-A ligands (L1 and L2) are investigated both experimentally and theoretically, aiming to explore efficient two-photon probes for bioimaging. Molecular geometry optimization used for theoretical calculations is achieved using the crystallographic data. Notably, the results indicate that complexes 1 and 2 display enhanced two-photon absorption (2PA) cross sections compared to their corresponding D-A ligand (L1). Furthermore, it was found that complex 1 has the advantages of moderate 2PA cross section in the near-infrared region, longer fluorescence lifetime, higher quantum yield, good biocompatibility and enhanced two-photon excited fluorescence. Therefore, complex 1 is evaluated as a bioimaging probe for in vitro imaging of HepG2 cells, in which it is observed under a two-photon scanning microscope that complex 1 exhibits effective co-staining with endoplasmic reticulum (ER) and nuclear membrane; as well as for in vivo imaging of zebrafish larva, in which it is observed that complex 1 exhibits specificity in the intestinal system.
Starting Page	7213
Ending Page	7221
Page Count	9
File Format	PDF HTM / HTML
DOI	10.1039/C5TB01185J
PubMed reference number	32262828
Journal	Medline
Volume Number	3
Issue Number	36
Alternate Webpage(s)	http://www.rsc.org/suppdata/c5/tb/c5tb01185j/c5tb01185j1.pdf
Journal	Journal of materials chemistry. B
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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