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Prognostic significance of argyrophilic nucleolar organizer region (AgNOR) in resected non-small cell lung cancer (NSCLC).
| Content Provider | Semantic Scholar |
|---|---|
| Author | Rodrigues, Olavo Ribeiro Antonângelo, Leila Yagi, Nobuaki Minamoto, Hélio Júnior, A. F. Schmidt Capelozzi, Vera Lúcia Goldenberg, Steve Saldiva, P. H. N. |
| Copyright Year | 1997 |
| Abstract | The expression of the nucleolar organizer regions (NORs) was quantified in paraffin sections of tumors and lymph node metastasis, by means of digital image analysis, in 75 patients with resected non-small cell lung cancer (NSCLC). Patients were divided in two groups: early stage (stages I and II) and advanced stage (stages IIIa, IIIb and IV). The prognostic significance of AgNOR expression was tested by Cox regression analysis in models controlled for age, sex, vital status, stage and histological type. Tumors at early stages had a lower expression of AgNOR than those at more advanced diseases. The mean values obtained for NORs in advanced disease were almost the same as those in the primary tumors when compared with the corresponding lymph node metastasis (r = 0.90; p < 0.01; linear regression). The prognostic role of AgNOR was significant only for tumors at stages I and II and not for advanced neoplasms (stages IIIa, IIIb and IV). These results encourage the inclusion of AgNOR quantitation in routine material, especially in early lung cancer. |
| Starting Page | 298 |
| Ending Page | 304 |
| Page Count | 7 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/jjco/27/5/10.1093/jjco/27.5.298/3/27-5-298.pdf?Expires=1491290681&Key-Pair-Id=APKAIUCZBIA4LVPAVW3Q&Signature=LR0mrlems~BPajyWekudPXG9hR-BlrZ2A65pZtnCMuylVD9Acxor21cgY0l3BR3o9Zyi3qysZ0VFeyTuAIh7D2KkgsX1E4VknxCHjfI7B-Lxho8dPQaUJyZ582Uk256dC0jHtlm~XyoOH9eDDyIjcs-XC6o2NT7nx86HzPk2qEdc7C54MrYJdKZ7OXDSiEOHheR1SYSH7mEpgYqcGNsPKaai6zb2dzJletpCmyj0e5QruX3-vC6xRk0VWx~afiZg4WP-6AG-VkgUUexl42qod0S3BfoPVvwAUtoFAwNDjvyrGKbPtV~EnlfSbpINLkodeky~J1fk9ZleMSxKK1U2UA__ |
| PubMed reference number | 9390205v1 |
| Volume Number | 27 |
| Issue Number | 5 |
| Journal | Japanese journal of clinical oncology |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Anatomic Node Limited stage (cancer stage) Neoplasms Nevus sebaceous Non-Small Cell Lung Carcinoma Nucleolar Organizer Region Nucleolus Organizer Region Patients Pineal Region Yolk Sac Tumor Quantitation Small cell carcinoma of lung lymph node metastases lymph nodes primary tumor |
| Content Type | Text |
| Resource Type | Article |
