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Circulating levels of perfluoroalkyl substances and prevalent diabetes in the elderly
| Content Provider | Semantic Scholar |
|---|---|
| Author | Lind, Lars Zethelius, Björn Salihovic, Samira Bavel, Bert Van Lind, P. Monica |
| Copyright Year | 2013 |
| Abstract | Aims/hypothesisSeveral environmental contaminants, such as polychlorinated biphenyls, dioxins, bisphenol A and phthalates, have been linked to diabetes. We therefore investigated whether other kinds of contaminants, perfluoroalkyl substances (PFAS), also called perfluorinated compounds (PFCs), are also associated with diabetes.MethodsThe Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study investigated 1,016 men and women aged 70 years. Seven PFAS were detected in almost all participant sera by ultra-high performance liquid chromatograph/tandem mass spectrometry. Diabetes was defined as use of hypoglycaemic agents or fasting glucose >7.0 mmol/l.Results114 people had diabetes. In the linear analysis, no significant relationships were seen between the seven PFAS and prevalent diabetes. However, inclusion of the quadratic terms of the PFAS revealed a significant non-linear relationship between perfluorononanoic acid (PFNA) and diabetes, even after adjusting for multiple confounders (OR 1.96, 95% CI 1.19, 3.22, p = 0.008 for the linear term and OR 1.25, 95% CI 1.08, 1.44, p = 0.002 for the quadratic term). Perfluorooctanoic acid (PFOA) also showed such a relationship (p = 0.01). PFOA was related to the proinsulin/insulin ratio (a marker of insulin secretion), but none of the PFAS was related to the HOMA-IR (a marker of insulin resistance) following adjustment for multiple confounders.Conclusions/interpretationPFNA was related to prevalent diabetes in a non-monotonic fashion in this cross-sectional study, supporting the view that this perfluoroalkyl substance might influence glucose metabolism in humans at the level of exposure seen in the general elderly population. |
| Starting Page | 473 |
| Ending Page | 479 |
| Page Count | 7 |
| File Format | PDF HTM / HTML |
| DOI | 10.1007/s00125-013-3126-3 |
| PubMed reference number | 24337155 |
| Journal | Medline |
| Volume Number | 57 |
| Alternate Webpage(s) | http://www.diabetologia-journal.org/files/Lind.pdf |
| Alternate Webpage(s) | http://www.medsci.uu.se/digitalAssets/158/c_158840-l_1-k_pfos-vs-diabetes.pdf |
| Journal | Diabetologia |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
