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Stimuli-Responsive Fluorescent Poly(N-isopropylacrylamide) Microgels Labeled with Phenylboronic Acid Moieties as Multifunctional Ratiometric Probes for Glucose and Temperatures
| Content Provider | Semantic Scholar |
|---|---|
| Author | Wang, Di Liu, Shiyong |
| Copyright Year | 2011 |
| Abstract | We report on the fabrication of multifunctional ratiometric probes for glucose and temperatures based on thermoresponsive poly(N-isopropylacrylamide) (PNIPAM) microgels covalently incorporated with glucose-recognizing moieties, N-acryloyl-3-aminophenylboronic acid (APBA), fluorescence resonance energy transfer (FRET) donor dyes, 4-(2-acryloyloxyethylamino)-7-nitro-2,1,3-benzoxadiazole (NBDAE), and rhodamine B-based FRET acceptors (RhBEA). P(NIPAM-APBA-NBDAE-RhBEA) microgels containing FRET pairs and APBA were synthesized via free radical emulsion copolymerization. The spatial proximity of FRET donors and acceptors within microgels can be tuned via thermo-induced microgel collapse or glucose-induced microgel swelling at appropriate pH and temperatures, leading to the facile modulation of FRET efficiencies. APBA moieties within P(NIPAM-APBA-NBDAE-RhBEA) microgels can bind with glucose at appropriate pH to form cyclic boronate moieties, which can decrease the pKa of APBA residues and increase the volume phas... |
| Starting Page | 2282 |
| Ending Page | 2290 |
| Page Count | 9 |
| File Format | PDF HTM / HTML |
| DOI | 10.1021/ma200053a |
| Alternate Webpage(s) | http://staff.ustc.edu.cn/~sliu/Papers/Macromolecules_2011_44_2282.pdf |
| Alternate Webpage(s) | https://doi.org/10.1021/ma200053a |
| Volume Number | 44 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
