Loading...
Please wait, while we are loading the content...
Similar Documents
Fiber intake and incidence of colorectal cancer among 76,947 women and 47,279 men.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Michels, Karin B. Fuchs, Charles S. Giovannucci, Edward L. Colditz, Graham A. Hunter, David J. Stampfer, Meir Jonathan Willett, Walter C. |
| Copyright Year | 2005 |
| Abstract | Prospective cohort studies have consistently found no important link between fiber intake and risk of colorectal cancer. The recent large, prospective European Prospective Investigation into Cancer and Nutrition has challenged this paradigm by suggesting significant protection by high fiber intake. We prospectively investigated the association of fiber intake with the incidence of colon and rectal cancers in two large cohorts: the Nurses' Health Study (76,947 women) and the Health Professionals Follow-up Study (47,279 men). Diet was assessed repeatedly in 1984, 1986, 1990, and 1994 among women and in 1986, 1990, and 1994 among men. The incidence of cancer of the colon and rectum was ascertained up to the year 2000. Relative risk estimates were calculated using a Cox proportional hazards model simultaneously controlling for potential confounding variables. During follow-up including 1.8 million person-years and 1,596 cases of colorectal cancer, we found little association with fiber intake after controlling for confounding variables. The hazard ratio for a 5-g/d increase in fiber intake was 0.91 (95% confidence interval, 0.87-0.95) after adjusting for covariates used in the European Prospective Investigation into Cancer and Nutrition study and 0.99 (95% confidence interval, 0.95-1.04) after adjusting for additional confounding variables. Our data from two large prospective cohorts with long follow-up and repeated assessment of fiber intake and of a large number of potential confounding variables do not indicate an important association between fiber intake and colorectal cancer but reveal considerable confounding by other dietary and lifestyle factors. |
| Starting Page | 596 |
| Ending Page | 607 |
| Page Count | 12 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://cebp.aacrjournals.org/content/cebp/14/4/842.full.pdf |
| PubMed reference number | 15824154v1 |
| Volume Number | 14 |
| Issue Number | 4 |
| Journal | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Colorectal Carcinoma Confidence Intervals Estimated Hazard Ratio Neoplasms Rectal Carcinoma Rectum TUBE,RECTAL,24FR,PLASTIC B#6510 |
| Content Type | Text |
| Resource Type | Article |
