NDLI: Inhibition of nitric oxide generation by 23,24-dihydrocucurbitacin D in mouse peritoneal macrophages.

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Inhibition of nitric oxide generation by 23,24-dihydrocucurbitacin D in mouse peritoneal macrophages.

Content Provider	Semantic Scholar
Author	Park, Chang Seok Lim, Hyun Han, Kee Jung Baek, Sun Heum Sohn, Hyung Ok Lee, Dong Wook Kim, Y. Yun, Hye-Young Baek, Kwang Jin Kwon, Nyoun Soo
Copyright Year	2004
Abstract	Nitric oxide (NO) has various physiological functions. However, uncontrolled overproduction of NO can be toxic in many pathologic conditions involving inflammatory tissue damage. In the present study, we examined effects of 23,24-dihydrocucurbitacin D (DHCD) isolated from the root of Bryonia alba L. on macrophage NO generation. DHCD (<80 microM) effectively abolished NO generation from macrophages activated with lipopolysaccharide and interferon-gamma. DHCD decreased the levels of protein and mRNA for inducible NO synthase (iNOS). DHCD potently blocked nuclear factor-kappaB (NF-kappaB) activation, a process necessary for transcriptional activation of iNOS. These results suggested that DHCD inhibited NO generation by blocking NF-kappaB activation and iNOS gene transcription. Because NF-kappaB activation is necessary not only for NO generation but also for many inflammatory processes, DHCD and its derivatives could be developed as anti-inflammatory drugs.
Starting Page	2040
Ending Page	2041
Page Count	2
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://jpet.aspetjournals.org/content/jpet/309/2/705.full.pdf
Alternate Webpage(s)	http://jpet.aspetjournals.org/content/early/2004/01/29/jpet.103.063693.full.pdf
PubMed reference number	14752064v1
Volume Number	309
Issue Number	2
Journal	The Journal of pharmacology and experimental therapeutics
Language	English
Access Restriction	Open
Subject Keyword	Anti-Inflammatory Agents Bryonia Eighty Interferon Type II Lipopolysaccharides Macrophages, Peritoneal NF-kappa B NOS2A protein, human Nitric Oxide Synthase Prostaglandin-Endoperoxide Synthase Soft Tissue Injuries Transcription, Genetic Transcriptional Activation
Content Type	Text
Resource Type	Article

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