NDLI: An estrogen receptor targeted ruthenium complex as a two-photon photodynamic therapy agent for breast cancer cells.

Content Provider	Semantic Scholar
Author	Zhao, Xueze Li, Mingle Fan, Jiangli Du, Jianjun Peng, Xiaojun
Copyright Year	2018
Abstract	In this study, we reported a tamoxifen modified Ru(ii) polypyridyl complex (Ru-tmxf) as an estrogen receptor (ER) targeted photosensitizer. Ru-tmxf displays enhanced cellular uptake and PDT efficiency toward breast cancer cells with high ER expression due to the specific targeting of tamoxifen to ER and finally localizes in lysosomes. Moreover, Ru-tmxf can be activated by two-photon excitation, generating 1O2 to damage lysosomes and result in cell death.
Starting Page	7038
Ending Page	7041
Page Count	4
File Format	PDF HTM / HTML
DOI	10.1039/c8cc03786h
Alternate Webpage(s)	http://www.rsc.org/suppdata/c8/cc/c8cc03786h/c8cc03786h1.pdf
PubMed reference number	29873358
Alternate Webpage(s)	https://doi.org/10.1039/c8cc03786h
Journal	Medline
Volume Number	54
Issue Number	51
Journal	Chemical communications
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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