Loading...
Please wait, while we are loading the content...
Similar Documents
Regional differences in the vulnerability of substantia nigra dopaminergic neurons in weaver mice.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Martí, Joaquín Santa-Cruz, María C. Molina, Vanessa Ventura Serra, Roger Bayer, Shirley A. Ghetti, Bernardino F. Hervás, José P. |
| Copyright Year | 2009 |
| Abstract | Vulnerability of midbrain dopaminergic (DA) neurons in the weaver mouse was studied at postnatal (P) days 8 and 90, in chosen coronal levels throughout the anteroposterior (AP) extent of the substantia nigra pars compacta (SNc). Wild-type (+/+) and homozygous weaver (wv/wv) mice used were the offspring of pregnant dams injected in several cases with tritiated thymidine on embryonic days 11-15. DA neurons were identified for their tyrosine hydroxylase immunoreactivity. Data reveal that at P8, the frequency of both +/+ and wv/wv late-generated DA cells increases from rostral to caudal SNc. No apparent DA-cell loss was observed at P8 in the mutant genotype, irrespective of the AP level considered. However, throughout the AP, there was a significant reduction in the number of these neurons at any level in 90-day-old weavers. Comparison of P8 and P90 +/+ SNc suggests that cell death is not a major aspect in the developmental regulation of normal DA neurons, although numerical cell depletion in the postnatal development of weaver SNc probably results from the amplification of a basal cell-death process, which affected all the coronal levels studied. |
| Starting Page | 198 |
| Ending Page | 206 |
| Page Count | 9 |
| File Format | PDF HTM / HTML |
| PubMed reference number | 19593334 |
| Journal | Medline |
| Volume Number | 69 |
| Issue Number | 2 |
| Alternate Webpage(s) | http://www.ane.pl/pdf/6922.pdf |
| Alternate Webpage(s) | https://www.ane.pl/pdf/6922.pdf |
| Journal | Acta neurobiologiae experimentalis |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
