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Clinical Evaluation of Tear Film Lipid Layer in Normal Subjects with Keratograph 5M
| Content Provider | Semantic Scholar |
|---|---|
| Author | Xu, Guihua Zhang, Liqin Chen, Jingcheng Chen, Zilin |
| Copyright Year | 2020 |
| Abstract | Objective: To investigate the changes of the tear film lipid layer thickness and factors relating tear film lipid layer thickness thinning in normal subjects with Keratograph 5M. Method: One hundred and thirty seven eyes of 79 normal subjects without ocular symptoms or ocular surface disorders were recruited in this study. The lid margin and the degree of ease of meibum were evaluated by slit-lamp microscopy. The Keratograph 5M (Oculus, Wetzlar, Germany) was used to evaluate the first non-invasive tear film break-up time (NITBUTf), the average non-invasive tear film break-up time (NITBUTavg), the images of tear film lipid layer and meibomian glands on every subject consecutively. A semi-automatic measurement with image J software was used to evaluate the meibomian glands loss on each subject. Statistical analysis was performed by using Stata 14.0. Multiple linear regression analysis was performed to investigate the factors that affect the tear film lipid layer thickness. Results: The mean age of 79 normal subjects was (43.89 ± 16.56) years. Of 137 normal eyes, 10 (8%) were defined as thick lipid layer, 50 eyes (41%) were moderate lipid layer, while more than half of them (62 eyes, 51%) were thin lipid layer. The mean score of the tear film layer thickness was 0.57 ± 0.64. Multiple linear regression analysis showed a significant negative correlation between tear film layer thickness and meibomian glands loss of lower eyelids (0.80 ± 0.74%). For each 1 percent meibomian glands loss in lower eyelids, the tear film layer thickness tended to be 10.12 times thinner (Coefficient = −10.12, P = 0.005). No correlation was found between lipid layer thickness and meibomian glands loss of upper eyelids (1.04 ± 0.76%) (Coefficient = 1.17, P = 0.744). Age, gender and the ease of the meibum expressed were not correlated with layer lipid thickness (P ≥ 0.282). Thinner tear film lipid layer was not significantly correlated with the stability of the tear film in normal subjects (P ≥ 0.459). Conclusions: The meibomian glands loss of lower eyelids was probably a significant factor for tear film lipid layer thinning in normal subjects. The more loss of the meibomian glands in lower lids, the thinner the tear film lipid layer is. Attention should be paid on the meibomian glands loss of lower eyelids as it may be cause tear film lipid layer thinning and dry eye. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://pdf.hanspub.org/HJO20200100000_25718951.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
