Extracellular-signal regulated kinase 1-dependent metabotropic glutamate receptor 5-induced long-term depression in the bed nucleus of the stria terminalis is disrupted by cocaine administration.

Content Provider	Semantic Scholar
Author	Grueter, Brad A. Gosnell, Heather B. Olsen, Christopher M. Schramm-Sapyta, Nicole L. Nekrasova, Tanya Landreth, Gary E. Winder, Danny G.
Copyright Year	2006
Abstract	The bed nucleus of the stria terminalis (BNST) is a key component of the CNS stress and reward circuit. Synaptic plasticity in this region could in part underlie the persistent behavioral alterations in generalized anxiety and addiction. Group I metabotropic glutamate receptors (mGluRs) have been implicated in stress, addiction, and synaptic plasticity, but their roles in the BNST are unknown. We find that activation of group I mGluRs in the dorsal BNST induces depression of excitatory synaptic transmission through two distinct mechanisms. First, a combined activation of group I mGluRs (mGluR1 and mGluR5) induces a transient depression that is cannabinoid 1 receptor dependent. Second, as with endocannabinoid-independent group I mGluR long-term depression (LTD) in the adult hippocampus, we find that activation of mGluR5 induces an extracellular signal-regulated kinase (ERK)-dependent LTD. Surprisingly, our data demonstrate that this LTD requires the ERK1 rather than ERK2 isoform, establishing a key role for this isoform in the CNS. Finally, we find that this LTD is dramatically reduced after multiple exposures but not a single exposure to cocaine, suggesting a role for this form of plasticity in the actions of psychostimulants on anxiety and reward circuitries and their emergent control of animal behavior.
Starting Page	1
Ending Page	15
Page Count	15
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.jneurosci.org/content/jneuro/26/12/3210.full.pdf
PubMed reference number	16554472v1
Volume Number	26
Issue Number	12
Journal	The Journal of neuroscience : the official journal of the Society for Neuroscience
Language	English
Access Restriction	Open
Subject Keyword	Addictive Behavior Anxiety Disorders Behavior, Animal Cannabinoids Cell Nucleus Cocaine Depressive disorder Endocannabinoids Glutamate Receptor Glutamic Acid Long-Term Synaptic Depression Mitogen-Activated Protein Kinase 3 Neuronal Plasticity Receptors, Metabotropic Glutamate Stria Synaptic Transmission
Content Type	Text
Resource Type	Article