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Obesity or diabetes: what is worse for the mother and for the baby?
| Content Provider | Semantic Scholar |
|---|---|
| Author | Bo, Simona Menato, Guido Signorile, Anna Lisa Bardelli, Chiara Lezo, Antonela Gallo, Matthieu Le Gambino, Roberto Cassader, Maurizio Massobrio, Marco Pagano, Gianfranco |
| Copyright Year | 2003 |
| Abstract | OBJECTIVES The aim of the present study is to evaluate pregnancy outcomes in a cohort of Caucasian pregnant women in relation to their body mass index and glucose tolerance status; the role of central fat distribution, as indicated by waist-to-hip circumference ratio, was also considered. METHODS Seven hundred women were studied; they had gestational diabetes or impaired glucose tolerance (250) or normoglycaemia (450). Among them 117 had pre-pregnancy overweight/obesity (44 were obese), 133 hyperglycaemia, but normal weight, and 117 hyperglycaemia and overweight/obesity (42 were obese). RESULTS Hypertension, cesarean delivery and prevalence of large-for-gestational age babies were higher in obese (both with normoglycaemia and hyperglycaemia), mainly in those with greater gestational weight gain and central fat distribution (waist-to-hip ratio > 0.90). Normal weight hyperglycaemic women showed better outcomes than obese normoglycaemic women did. In a multiple logistic regression model, obesity (OR=10.6; 95% CI 5.00-22.54) was directly related to hypertension, and independent predictors of cesarean section were: gestational hyperglycaemia (OR=1.78; 95% CI 1.21-2.62), gestational weight gain (OR=1.06; 95% CI 1.02-1.10), and central obesity (OR=1.51; 95% CI 1.02-2.24), while obesity (OR=4.48; 95% CI 2.30-8.71) gestational weight gain (OR=1.08; 95% CI 1.03-1.12) and central fat distribution (OR=1.81: 95% CI 1.12-2.93) were directly related to delivering larger babies, after multiple adjustments. CONCLUSION These results suggest that pre-pregnancy obesity and gestational hyperglycaemia were independent risk factors for different adverse pregnancy and neonatal outcomes, while central distribution of fat, and gestational weight gain play an additive adverse role on these outcomes. |
| File Format | PDF HTM / HTML |
| PubMed reference number | 12746640 |
| Journal | Medline |
| Volume Number | 29 |
| Issue Number | 2 |
| Part | 1 |
| Alternate Webpage(s) | https://www.em-consulte.com/showarticlefile/80184/pdf_49103.pdf |
| Alternate Webpage(s) | http://www.em-consulte.com/showarticlefile/80184/pdf_49103.pdf |
| Alternate Webpage(s) | https://doi.org/10.1016/S1262-3636%2807%2970026-5 |
| Journal | Diabetes & metabolism |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
