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P219 Dementia, mild cognitive impairment and quantitative EEG in patients with Parkinson's Disease
| Content Provider | Semantic Scholar |
|---|---|
| Author | Tedrus, Gloria Maria A. S. Fonseca, Lineu Letro, Grace Helena Bossoni, Alexandre Souza |
| Copyright Year | 2008 |
| Description | Previous studies indicated that intra-hippocampal injections of Naltrexone as a classic antagonist of opioid receptor blocked glucocorticoid-induced deficit in memory retrieval, but the sort of opioid receptor that interaction with glucocorticoids were not known. The present study examined whether the kappa opioid receptors in the hippocampus interact with glucocorticoid effects on memory retrieval in a water maze (WM). 140 young rats (250-300 gr) carrying bilateral cannulae aimed at the hippocampus were trained in a WM task with six trials per day for six consecutive days. Retention of the spatial training was assessed 24h after the last training session with a 60-s probe trial. Corticosterone (1mg/kg) was injected 30 min before retention testing with or without prior bilateral intra-hippocampal injections of U111 (0.8, 2, 5 μg/0.5 μl per site) as a kappa opioid receptor agonist or N-BNI (0.75, 1.5 and 3 μg/0.5 μl per site) as a kappa opioid receptor antagonist. The results show that corticosterone-induced impairment of memory retrieval. But U111 and N-BNI donot effects on corticostron's effects significantly (P>0.05). These findings provide evidence for the view those glucocorticoids havenot interact with the hippocampal kappa opioid receptors in influencing long-term memory retrieval. |
| Starting Page | s126 |
| Ending Page | s127 |
| Page Count | 2 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/S1388-2457(08)60490-3 |
| Volume Number | 119 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/S1388245708604903 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/S1388245708604903?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/S1388-2457%2808%2960490-3 |
| Journal | Clinical Neurophysiology |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Synopsis |
