Loading...
Please wait, while we are loading the content...
Similar Documents
Low-dose proton beam therapy for circumscribed choroidal hemangiomas.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Frau, Eric Rumen, Frank Noel, George Delacroix, Sabine Habrand, J. L. Offret, Hervé |
| Copyright Year | 2004 |
| Abstract | OBJECTIVE To evaluate the efficacy and safety of proton beam therapy for complicated circumscribed choroidal hemangiomas. METHODS The study was a retrospective nonrandomized investigation. Seventeen consecutive patients, referred to the Institut Gustave-Roussy, Villejuif, France, for circumscribed choroidal hemangioma associated with serous retinal detachment were studied. Each eye received a total dose of 20 cobalt gray equivalents (CGEs) delivered in 15-second fractions of 5 CGEs over 4 days. Functional tests included the initial and final best-corrected visual acuity, slitlamp examination, intraocular pressure, fundus examination, fluorescein angiography, and indocyanine green angiography. Tumor thickness was determined on B-scan ultrasonography. RESULTS The macula was involved in 7 eyes and the lesion was juxtapapillary in 2 eyes. The mean (SD) tumor thickness was 3.06 (9.0) mm. The mean initial tumor diameter was 6.82 mm (range, 3.2-12.1 mm). The right eye was involved in 7 cases and the left eye in 10 cases. The mean (SD) follow-up period was 52 (58) months (range, 36-90 months). Retinal reattachment was obtained in all cases after a mean period of 2 months (range, 1-12 months; median, 1 month). Tumor regression was obtained in all cases. One recurrence occurred 1 year after the initial treatment in an undertreated area. After re-treatment, however, resolution of the retinal detachment occurred, and flattening of the choroidal lesion was obtained. Final visual acuity improved to 2 Snellen lines or more in 16 eyes (94%), was stable in 1 eye, and attained 20/40 or more in 12 eyes (70.6%). No radiation therapy complications occurred during follow-up. CONCLUSIONS Proton beam therapy for choroidal hemangiomas seems to be an effective and safe alternative option. A total dose of 20 CGEs delivered in 4 daily 15-second fractions of 5 CGEs seems adequate for local control of both the tumor and serous retinal detachment. |
| Starting Page | 78 |
| Ending Page | 84 |
| Page Count | 7 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://archopht.jamanetwork.com/journals/ophth/articlepdf/416606/ecs30205.pdf |
| Alternate Webpage(s) | https://archopht.jamanetwork.com/journals/OPHTH/articlepdf/416606/ecs30205.pdf |
| PubMed reference number | 15477458v1 |
| Volume Number | 122 |
| Issue Number | 10 |
| Journal | Archives of ophthalmology |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Carcinogenicity Tests Choroid Hemorrhage Choroidal Neovascularization Choroidal hemangioma Circumscribe (action) Cobalt Cobalt:SCnc:Pt:Bld:Qn Diameter (qualifier value) Equivalent Weight Exudative retinal detachment Eye Abnormalities Fluorescein Angiography Follow-Up Report Indocyanine Green Neoplasms Patients Physiological Sexual Disorders Proton Therapy Retina Right eye angiogram |
| Content Type | Text |
| Resource Type | Article |
