Effects of high-density lipoprotein elevation with cholesteryl ester transfer protein inhibition on insulin secretion.

Content Provider	Semantic Scholar
Author	Siebel, Andrew L. Natoli, Alaina K. Yap, F. W. Carey, Andrew L. Reddy-luthmoodoo, Medini Sviridov, Dmitri Weber, Chek Ing Kiu Meneses-Lorente, Georgina Maugeais, Cyrille Forbes, Josephine M. Kingwell, Bronwyn A.
Copyright Year	2013
Abstract	RATIONALE High-density lipoprotein cholesterol elevation via cholesteryl ester transfer protein (CETP) inhibition represents a novel therapy for atherosclerosis, which also may have relevance for type 2 diabetes mellitus. OBJECTIVE The current study assessed the effects of a CETP inhibitor on postprandial insulin, ex vivo insulin secretion, and cholesterol efflux from pancreatic β-cells. METHODS AND RESULTS Healthy participants received a daily dose of CETP inhibitor (n=10) or placebo (n=15) for 14 days in a randomized double-blind study. Insulin secretion and cholesterol efflux from MIN6N8 β-cells were determined after incubation with treated plasma. CETP inhibition increased plasma high-density lipoprotein cholesterol, apolipoprotein AI, and postprandial insulin. MIN6N8 β-cells incubated with plasma from CETP inhibitor-treated individuals (compared with placebo) exhibited an increase in both glucose-stimulated insulin secretion and cholesterol efflux over the 14-day treatment period. CONCLUSIONS CETP inhibition increased postprandial insulin and promoted ex vivo β-cell glucose-stimulated insulin secretion, potentially via enhanced β-cell cholesterol efflux.
Starting Page	175
Ending Page	185
Page Count	11
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://circres.ahajournals.org/content/circresaha/113/2/167.full.pdf?download=true
Alternate Webpage(s)	http://circresaha.smart01.highwire.org/content/circresaha/113/2/167.full.pdf?download=true
PubMed reference number	23676183v1
Alternate Webpage(s)	https://doi.org/10.1161/CIRCRESAHA.113.300689
DOI	10.1161/circresaha.113.300689
Journal	Circulation research
Volume Number	113
Issue Number	2
Language	English
Access Restriction	Open
Subject Keyword	Aortic Valve Insufficiency Apolipoprotein A-I Apolipoproteins Atherosclerosis Cholesterol Ester Transfer Proteins Cholesterol Esters Diabetes Mellitus Diabetes Mellitus, Non-Insulin-Dependent Glucose Lipoproteins cholesterol efflux incubated insulin secretion
Content Type	Text
Resource Type	Article