NDLI: Measurement of haloperidol reductase activity in red blood cells and reduced haloperidol/ haloperidol ratios in plasma in oriental psychiatric patients

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Measurement of haloperidol reductase activity in red blood cells and reduced haloperidol/ haloperidol ratios in plasma in oriental psychiatric patients

Content Provider	Semantic Scholar
Author	Morikazu, Shibasaki Toshiyuki, Someya Tadafumi, Kato Toshifumi, Noguchi Saburo, Takahashi
Copyright Year	1990
Abstract	Abstract Shibaski Morikazu, Toshiyuki Someya, Tadafumi Kato, Toshifumi Noguchi, Nobuya Ishida and Saburo Takahashi: Measurement of Haloperidol Reductase Activity in Red Blood Cells and Reduced Haloperidol/ Haloperidol Ratios in Plasma in Oriental Psychiatric Patients. Prog. Neuro-Psychopharmacol. & Biol. Psychiat. 1990, 14 : 941–947. 1. 1. The authors established a method for measuring haloperidol (HAL) reductase activity in human red blood cells. 2. 2. Characteristics of the HAL reductase in red blood cells were examined. This enzyme reaction was NADPH dependent, and the optimum pH was at 8.2–8.9. Vmax and Km were calculated as 25–150 pmol/hr/10 6 RBC and 160–2600 μM respectively. 3. 3. HAL reductase activities in red blood cells from 14 patients treated with HAL were in a range of 9.7–20.8 pmol/hr/10 6 RBC. So far we did not find any significant correlation between HAL reductase activities and reduced HAL/HAL ratios in plasma.
Starting Page	143
Ending Page	154
Page Count	12
File Format	PDF HTM / HTML
DOI	10.1016/0278-5846(90)90079-V
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/027858469090079V
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/027858469090079V?dgcid=api_sd_search-api-endpoint
Alternate Webpage(s)	https://doi.org/10.1016/0278-5846%2890%2990079-V
Volume Number	14
Journal	Progress in Neuro-Psychopharmacology and Biological Psychiatry
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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