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Atrial natriuretic peptide: an essential physiological regulator of transvascular fluid, protein transport, and plasma volume.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Curry, Fitz-Roy |
| Copyright Year | 2005 |
| Abstract | Atrial natriuretic peptide (ANP) acts acutely to reduce plasma volume by at least 3 mechanisms: increased renal excretion of salt and water, vasodilation, and increased vascular permeability. Authors of a study in this issue of the JCI performed a knockout of the receptor for ANP in vascular endothelia in order to distinguish the effects of ANP-dependent increases in vascular permeability from those of other endocrine actions of ANP in the regulation of plasma volume. The knockout mice exhibited reduced vascular permeability to plasma protein, resulting in chronically increased plasma volume, arterial hypertension, and cardiac hypertrophy. Renal excretion and vasodilation did not account for these changes. Thus ANP-induced increases in endothelial permeability may be critical to the ability of ANP to lower arterial blood pressure. |
| Starting Page | 1 |
| Ending Page | 2 |
| Page Count | 2 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://www.jci.org/articles/view/25417/pdf/render |
| Alternate Webpage(s) | http://dm5migu4zj3pb.cloudfront.net/manuscripts/25000/25417/JCI0525417.pdf |
| Alternate Webpage(s) | http://www.jci.org/articles/view/25417/version/1/pdf/render |
| PubMed reference number | 15931381v1 |
| Volume Number | 115 |
| Issue Number | 6 |
| Journal | The Journal of clinical investigation |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Blood Plasma Volume Cardiac Hypertrophy Heart Atrium Hypertensive disease Kidney Diseases Nesiritide Renal Elimination Sodium Chloride Vasodilation disorder intracellular protein transport |
| Content Type | Text |
| Resource Type | Article |
