NDLI: Phase I trial of SAR103168, a novel multi-kinase inhibitor, in patients with refractory/relapsed acute leukemia or high-risk myelodysplastic syndrome.

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Phase I trial of SAR103168, a novel multi-kinase inhibitor, in patients with refractory/relapsed acute leukemia or high-risk myelodysplastic syndrome.

Content Provider	Semantic Scholar
Author	Roboz, Gail J. Khoury, H. Jean Jabbour, Elias Joseph Session, Wilena Ritchie, Ellen Kelly Miao, Harry H. Faderl, Stefan H. Zheng, Wei Feldman, Eric J. Arellano, Martha Morrison, James Gilmour Ravandi, Farhad
Copyright Year	2015
Abstract	There is no effective treatment for relapsed/refractory acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). We conducted a phase I dose escalation trial of SAR103168, a novel multi-targeted kinase inhibitor with activity against the Src kinase family, the BCR-Abl kinase and several angiogenic receptor kinases. Twenty-nine patients 18-83 years old were treated with SAR103168. Pharmacokinetics was characterized by plasma peak concentration (Cmax) at the end of the infusion, followed by a biphasic decline in the elimination profile. Adverse events were as expected for the patient population and there were no individual toxicities specific to SAR103168. Due to the unpredictable nature of drug exposure, the sponsor decided to discontinue the study prior to reaching the maximum tolerated dose.
Starting Page	395
Ending Page	400
Page Count	6
File Format	PDF HTM / HTML
DOI	10.3109/10428194.2014.918970
PubMed reference number	24794806
Journal	Medline
Volume Number	56
Issue Number	2
Journal	Leukemia & lymphoma
Alternate Webpage(s)	https://open.library.emory.edu/publications/emory:s3t41/pdf/
Alternate Webpage(s)	https://doi.org/10.3109/10428194.2014.918970
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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