NDLI: Effects of barbiturates on GABA system: comparison to alcohol and benzodiazepines.

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Effects of barbiturates on GABA system: comparison to alcohol and benzodiazepines.

Content Provider	Semantic Scholar
Author	Yu, Sidney Siu Bun
Copyright Year	1991
Abstract	Central nervous system depressants, e.g. barbiturates, alcohol and benzodiazepines, have a wide spectrum of activity in humans and animals. Evidence accumulated suggests that some of the pharmacological actions exerted by these agents may be mediated through GABA system by mimicking GABAergic transmission. This proceeding briefly summarizes the evidence presented in our previous review (Yu S and Ho Ik: Alcohol 7: 261, 1990) as to how the GABA system plays a part in the barbiturate actions and the development of tolerance to and physical dependence on barbiturates. The comparisons of the effects of alcohol, barbiturates and benzodiazepines at different steps of GABA synapse are also discussed. Furthermore, the results which have been reported in the literature are inconsistent. This may be due to differences in (a) animal models used; (b) brain regions used; (c) protocols (dose, duration, form and route of administration, etc.) used in treating animals and/or (d) techniques (pharmacological, biochemical, physiological, etc.) used.
Starting Page	577
Ending Page	584
Page Count	8
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://www.jstage.jst.go.jp/article/kjm1952/40/4/40_4_183/_pdf
PubMed reference number	1687071v1
Volume Number	40
Issue Number	4
Journal	The Keio journal of medicine
Language	English
Access Restriction	Open
Subject Keyword	Animal Model Barbiturates Benzodiazepines CNS disorder Central Nervous System Depressants Ethanol Nervous system structure Pharmacology Protocols documentation gamma-Aminobutyric Acid physical dependence physical hard work
Content Type	Text
Resource Type	Article

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