NDLI: Efeitos do ômega-3 na autofagia do músculo cardíaco de camundongos mdx

Content Provider	Semantic Scholar
Author	Furlan, Stephanie De Souza Marques, Maria Julia Pereira, Juliano Gil Alves Neto, Humberto Santo
Copyright Year	2016
Abstract	Resumo A Distrofia Muscular de Duchenne (DMD) é uma distrofinopatia caracterizada pela falta de distrofina, que acarreta mionecrose e inflamação, sendo a autofagia diminuída. O camundongo mdx é o modelo experimental da DMD. Corticoides são empregados no tratamento convencional da DMD; no entanto seus efeitos colaterais incentivam a busca por novas terapias. O ômega-3 diminui a inflamação e mionecrose em músculos cardíacos de animais distróficos. No presente estudo demonstramos que o ômega-3, no músculo cardíaco, aumentou a autofagia, como verificado pela expressão de LC3 (microtubule-associated protein 1 light chain 3) e reduziu a mionecrose, verificado pelo aumento de Troponina I. Concluímos que o ômega-3 contribui para a integridade da fibra muscular cardíaca por atuar nos processos autofágicos.
Starting Page	50616
Ending Page	50616
Page Count	1
File Format	PDF HTM / HTML
DOI	10.19146/pibic-2016-50616
Alternate Webpage(s)	https://proceedings.science/proceedings/48/_papers/50616/download/abstract_file1?lang=pt-br
Alternate Webpage(s)	https://proceedings.science/proceedings/48/_papers/50616/download/abstract_file1
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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