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D-cycloserine, a positive modulator of the N-methyl-D-aspartate receptor, enhances performance of learning tasks in rats
| Content Provider | Semantic Scholar |
|---|---|
| Author | Monahan, Joseph B. Handelmann, Gail E. Hood, William F. Cordi, Alexis A. |
| Copyright Year | 1989 |
| Abstract | Glycine has recently been shown to positively modulate the N-methyl-D-aspartate (NMDA) subclass of acidic amino acid receptors which are important in neural pathways involved in learning and memory. We report that d-cycloserine (DCS), an antimycobacterial agent known to cross the blood-brain barrier, binds with high affinity to this glycine modulatory site, functions as a positive modulator, and facilitates performance of learning tasks in rats. In addition, DCS appears to be a potent cognitive enhancer at doses lower than those required for antibacterial activity. Based on these data, we propose that modulation of NMDA receptors via glycinergic mechanisms may be a means of influencing cognitive processes. |
| Starting Page | 649 |
| Ending Page | 653 |
| Page Count | 5 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/0091-3057(89)90571-6 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/0091305789905716 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/0091305789905716?dgcid=api_sd_search-api-endpoint |
| PubMed reference number | 2560209 |
| Alternate Webpage(s) | https://doi.org/10.1016/0091-3057%2889%2990571-6 |
| Journal | Medline |
| Volume Number | 34 |
| Journal | Pharmacology Biochemistry and Behavior |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
