Loading...
Please wait, while we are loading the content...
Similar Documents
Cancer-causing somatic mutations: they are neither necessary nor sufficient
| Content Provider | Semantic Scholar |
|---|---|
| Author | Sonnenschein, Carlos Soto, Ana M. |
| Copyright Year | 2018 |
| Abstract | For over a century, the somatic mutation theory of carcinogenesis (SMT) has been adopted by researchers as the theory of record to explain the vast bio-medical implications of the cancer disease. Central to this theory is the notion that mutated alleged cancer genes are responsible for the cancer phenotype(s). Despite generous sustained funding and unwavering research commitments, the presence and the roles of genomic mutations remain undefined and controversial. Our analysis of the merits of causatively linking mutated cancer genes and cancer phenotypes suggests that such mutations are neither necessary nor sufficient. |
| Starting Page | 55 |
| Ending Page | 62 |
| Page Count | 8 |
| File Format | PDF HTM / HTML |
| DOI | 10.13133/2532-5876_3.12 |
| Volume Number | 2 |
| Alternate Webpage(s) | https://ojs.uniroma1.it/index.php/Organisms/article/download/14312/14041 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
