Chronic neuroleptic administration decreases extracellular GABA in the nucleus accumbens but not in the caudate-putamen of rats

Content Provider	Semantic Scholar
Author	See, Ronald E. Chapman, Mary Ann Klitenick, Mark A.
Copyright Year	1992
Abstract	The extracellular levels of gamma-aminobutyric acid (GABA) in the caudate-putamen and the nucleus accumbens of rats following administration of haloperidol decanoate, fluphenazine decanoate, or vehicle for 8 months were assessed using intracranial microdialysis. Basal levels of extracellular GABA were significantly decreased in the nucleus accumbens of both neuroleptic-treated groups while levels of GABA in the caudate-putamen were not significantly different between groups. These results provide evidence for selective chronic neuroleptic-induced effects on in vivo GABA function in different terminal regions containing dopamine receptors.
Starting Page	177
Ending Page	180
Page Count	4
File Format	PDF HTM / HTML
DOI	10.1016/0006-8993(92)91361-H
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/000689939291361H
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/000689939291361H?dgcid=api_sd_search-api-endpoint
PubMed reference number	1356587
Alternate Webpage(s)	https://doi.org/10.1016/0006-8993%2892%2991361-H
Journal	Medline
Volume Number	588
Journal	Brain Research
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article