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Effects of Whey Protein Hydrolysates on Lipid Profiles and Appetite-Related Hormones in Rats Fed High Fat Diet
| Content Provider | Semantic Scholar |
|---|---|
| Author | Park, Jung-Yoon Park, Mi-Na Choi, You-Young Yun, Sung-Seob Chun, Ho-Nam Lee, Yeon-Sook |
| Copyright Year | 2008 |
| Abstract | This study was carried out to compare the effects of whey protein concentrate, its hydrolysates and macropeptide fractions obtained from papain treatment of whey protein on lipid levels and appetite-related hormones in obesity model rats induced by high fat diet. Four week-old male Sprague-Dawley rats were fed high fat (18% w/w) and low protein (10% w/w) diet for 4 weeks and then divided into four groups (n=8/group). Rats were fed high fat diets containing various nitrogen sources; 10% whey protein concentrate (10WPC), 25% whey protein concentrate (25WPC), 25% whey protein hydrolysates (25WH), and 25% whey macropeptide fractions (25WP, MW≥10,000), respectively for 6 weeks. There were no significant differences in body weight gain and food intake among groups. A significant decrease of total lipid, triglyceride in serum was observed in 25WH and 25WP groups. Total lipid and triglyceride contents of the liver were significantly decreased in 25WPC, 25WH and 25WP groups compared with 10WPC group. However, in the liver, there were no differences in the contents of total lipid and triglyceride among 25WPC, 25WH and 25WP groups. The daily amounts of feces were significantly increased in 25WH and 25WP groups and the excretion of total lipid and triglyceride were significantly increased in 25WH group. Serum glucose and insulin concentration were significantly decreased in 25WH group. The concentration of serum ghrelin was significantly decreased in the 25WPC, 25WH and 25WP groups compared with 10WPC group. However, there was no significant difference in the concentration of serum leptin among groups. These results suggest that whey protein hydrolysates and macropeptide fractions may show beneficial effects on the lipid profile in serum and liver, appetite regulation and insulin resistance in obesity model rats induced by high fat diet. |
| Starting Page | 428 |
| Ending Page | 436 |
| Page Count | 9 |
| File Format | PDF HTM / HTML |
| DOI | 10.3746/jkfn.2008.37.4.428 |
| Volume Number | 37 |
| Alternate Webpage(s) | http://ocean.kisti.re.kr/downfile/volume/kfn/SPOOBG/2008/v37n4/SPOOBG_2008_v37n4_428.pdf |
| Alternate Webpage(s) | https://doi.org/10.3746/jkfn.2008.37.4.428 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
