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The Effects of N-acetyl-seryl-aspartyl-lysyl-proline on Expression of NF-κ b and MCP-1 in Rats with Silicosis
| Content Provider | Semantic Scholar |
|---|---|
| Author | Li, Qian Yang, Fang Zhang, Lijuan Zhang, Wenli |
| Copyright Year | 2013 |
| Abstract | In the present study, we developed silicosis of rat model by bronchial perfusion SiO2 dust, and intervenes with AcSDKP, immunohisto chemistry was used to detect NF-κb and MCP-1 expression in lung tissue, and positive cells were counted. We found that compared with silicotic model group, the positive cells of NF-κb and MCP-1 were decreased significantly in anti-fibrosis treatment of AcSDKP group. The findings suggest that AcSDKP could inhibit the expression of NF-κb and MCP-1 in lung tissue of silicosos, this may be related to AcSDKP inhibit of macrophage infiltration in lung tissue and reduced the degree of dust alveolitis. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://file.scirp.org/pdf/IJCCE_2013072416032549.pdf |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Alveolitis Fibrosis Procollagen-Proline Dioxygenase Proline Silicosis Structure of parenchyma of lung goralatide |
| Content Type | Text |
| Resource Type | Article |
