NDLI: Mechanochemical Friedel–Crafts acylations

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Mechanochemical Friedel–Crafts acylations

Content Provider	Semantic Scholar
Author	Đud, Mateja Briš, Anamarija Jušinski, Iva Gracin, Davor Margetić, Davor
Copyright Year	2019
Abstract	Friedel-Crafts (FC) acylation reactions were exploited in the preparation of ketone-functionalized aromatics. Environmentally more friendly, solvent-free mechanochemical reaction conditions of this industrially important reaction were developed. Reaction parameters such as FC catalyst, time, ratio of reagents and milling support were studied to establish the optimal reaction conditions. The scope of the reaction was explored by employment of different aromatic hydrocarbons in conjunction with anhydrides and acylation reagents. It was shown that certain FC-reactive aromatics could be effectively functionalized by FC acylations carried out under ball-milling conditions without the presence of a solvent. The reaction mechanism was studied by in situ Raman and ex situ IR spectroscopy.
Starting Page	1313
Ending Page	1320
Page Count	8
File Format	PDF HTM / HTML
DOI	10.3762/bjoc.15.130
PubMed reference number	31293680
Journal	Medline
Volume Number	15
Alternate Webpage(s)	https://www.beilstein-journals.org/bjoc/content/supplementary/1860-5397-15-130-S1.pdf
Alternate Webpage(s)	https://doi.org/10.3762/bjoc.15.130
Journal	Beilstein journal of organic chemistry
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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