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European League Against Rheumatism (EULAR) recommendations for the management of psoriatic arthritis with pharmacological therapies: 2015 update.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Gossec, Laure Smolen, Josef S. Ramiro, Sofia Wit, Martinus De Cutolo, Maurizio Dougados, Maxime R. Emery, Paul Landewé, Robert L. Oliver, Susan Mary Aletaha, Daniel Betteridge, Neil Braun, J. Burmester, Gerd Rüdiger Cañete, Juan D. Damjanov, Nemanja Fitzgerald, Oliver M. Haglund, Emma Helliwell, Philip S. Kvien, Tore Kristian Lories, Rik J. Luger, Thomas Anton Maccarone, Mara Marzo-Ortega, Helena McGonagle, Denis McInnes, Iain B. Olivieri, Irene Hardwicke Bensen, William Schett, Georg Sieper, Joachim Bosch, Filip E. Van Den Veale, Douglas J. Wollenhaupt, Juergen Zink, Angela Heijde, Désirée Mfm Van Der |
| Copyright Year | 2016 |
| Abstract | BACKGROUND Since the publication of the European League Against Rheumatism recommendations for the pharmacological treatment of psoriatic arthritis (PsA) in 2012, new evidence and new therapeutic agents have emerged. The objective was to update these recommendations. METHODS A systematic literature review was performed regarding pharmacological treatment in PsA. Subsequently, recommendations were formulated based on the evidence and the expert opinion of the 34 Task Force members. Levels of evidence and strengths of recommendations were allocated. RESULTS The updated recommendations comprise 5 overarching principles and 10 recommendations, covering pharmacological therapies for PsA from non-steroidal anti-inflammatory drugs (NSAIDs), to conventional synthetic (csDMARD) and biological (bDMARD) disease-modifying antirheumatic drugs, whatever their mode of action, taking articular and extra-articular manifestations of PsA into account, but focusing on musculoskeletal involvement. The overarching principles address the need for shared decision-making and treatment objectives. The recommendations address csDMARDs as an initial therapy after failure of NSAIDs and local therapy for active disease, followed, if necessary, by a bDMARD or a targeted synthetic DMARD (tsDMARD). The first bDMARD would usually be a tumour necrosis factor (TNF) inhibitor. bDMARDs targeting interleukin (IL)12/23 (ustekinumab) or IL-17 pathways (secukinumab) may be used in patients for whom TNF inhibitors are inappropriate and a tsDMARD such as a phosphodiesterase 4-inhibitor (apremilast) if bDMARDs are inappropriate. If the first bDMARD strategy fails, any other bDMARD or tsDMARD may be used. CONCLUSIONS These recommendations provide stakeholders with an updated consensus on the pharmacological treatment of PsA and strategies to reach optimal outcomes in PsA, based on a combination of evidence and expert opinion. |
| Starting Page | 499 |
| Ending Page | 510 |
| Page Count | 12 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://ard.bmj.com/content/annrheumdis/75/3/499.full.pdf |
| Alternate Webpage(s) | http://ard.bmj.com/content/annrheumdis/early/2015/12/07/annrheumdis-2015-208337.full.pdf |
| PubMed reference number | 26644232v1 |
| Alternate Webpage(s) | https://doi.org/10.1136/annrheumdis-2015-208337 |
| DOI | 10.1136/annrheumdis-2015-208337 |
| Journal | Annals of the rheumatic diseases |
| Volume Number | 75 |
| Issue Number | 3 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Anti-Inflammatory Agents Anti-Inflammatory Agents, Non-Steroidal Antirheumatic Agents Antirheumatic Drugs, Disease-Modifying Arthritis Arthritis, Psoriatic Collagen Diseases Decision Making Patients Pharmacology Recombinant Interleukins Therapeutic procedure Tumor Necrosis Factors apremilast cellular targeting ustekinumab |
| Content Type | Text |
| Resource Type | Article |
