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Acute and repeated administration of sulpiride alters Met- and Leu-enkephalin content of rat brain
| Content Provider | Semantic Scholar |
|---|---|
| Author | Ceballos, M. L. De Jenner, Peter Marsden, C. David |
| Copyright Year | 1986 |
| Abstract | Following acute administration of sulpiride (100 mg/kg, i.p.), Met-enkephalin levels were increased in striatum but decreased in substantia nigra and nucleus accumbens. No effect was observed in hypothalamus or frontal cortex. In contrast, Leu-enkephalin content was decreased in the nucleus accumbens but not elsewhere. Administration of sulpiride (10 or 100 mg/kg, i.p.) for 21 days, followed by 2 days drug withdrawal, caused a dose-dependent increase in Met-enkephalin in nucleus accumbens but decreases in hypothalamus and frontal cortex. No change was observed in the striatum or substantia nigra. Repeated sulpiride administration caused a decrease in Leu-enkephalin content of the hypothalamus and cortex but not elsewhere. |
| Starting Page | 322 |
| Ending Page | 326 |
| Page Count | 5 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/0304-3940(86)90510-0 |
| PubMed reference number | 3748458 |
| Journal | Medline |
| Volume Number | 68 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/0304394086905100 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/0304394086905100?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/0304-3940%2886%2990510-0 |
| Journal | Neuroscience Letters |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
