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HLA mismatches and hematopoietic cell transplantation: structural simulations assess the impact of changes in peptide binding specificity on transplant outcome
| Content Provider | Semantic Scholar |
|---|---|
| Author | Yanover, Chen Petersdorf, Effie W. Malkki, Mari Gooley, Ted A. Spellman, Stephen R. Velardi, Andrea Bardy, Peter Madrigal, Alejandro Bignon, Jean-Denis Bradley, Philip |
| Copyright Year | 2011 |
| Abstract | The success of hematopoietic cell transplantation from an unrelated donor depends in part on the degree of Human Histocompatibility Leukocyte Antigen (HLA) matching between donor and patient. We present a structure-based analysis of HLA mismatching, focusing on individual amino acid mismatches and their effect on peptide binding specificity. Using molecular modeling simulations of HLA-peptide interactions, we find evidence that amino acid mismatches predicted to perturb peptide binding specificity are associated with higher risk of mortality in a large and diverse dataset of patient-donor pairs assembled by the International Histocompatibility Working Group in Hematopoietic Cell Transplantation consortium. This analysis may represent a first step toward sequence-based prediction of relative risk for HLA allele mismatches. |
| File Format | PDF HTM / HTML |
| DOI | 10.4172/1745-7580.1000048 |
| PubMed reference number | 24482668 |
| Journal | Medline |
| Volume Number | 7 |
| Alternate Webpage(s) | https://www.scienceopen.com/document_file/6edff153-b0b5-4974-8adf-5ec24106850d/PubMedCentral/6edff153-b0b5-4974-8adf-5ec24106850d.pdf |
| Alternate Webpage(s) | https://doi.org/10.4172/1745-7580.1000048 |
| Journal | Immunome research |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
