NDLI: Thermodynamic study of lanthanide(III) complexes with bifunctional monophosphinic acid analogues of H4dota and comparative kinetic study of yttrium(III) complexes.

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Thermodynamic study of lanthanide(III) complexes with bifunctional monophosphinic acid analogues of H4dota and comparative kinetic study of yttrium(III) complexes.

Content Provider	Semantic Scholar
Author	Försterová, Michaela Svobodová, Ivona Lubal, Přemysl Táborský, Petr Kotek, Jan Hermann, Petr Lukeš, Ivan
Copyright Year	2007
Abstract	New bifunctional H(4)dota-like ligands with three acetic acid and one phosphinic acid pendant arms and propionate (H(5)do3ap(PrA)) or 4-aminobenzyl (H(4)do3ap(ABn)) reactive groups bound to the phosphorus atom were investigated. Potentiometric studies showed that the ligands have a similar basicity to the parent H(4)dota and the stability constants of their complexes with sodium(i) and selected lanthanide(III) ions are also similar. Formation and acid-assisted decomplexation kinetics of yttrium(III) complexes with a series of H(4)dota-like ligands (H(4)dota and its phosphinic/phosphonic acid analogues) were studied and the reactions are sensitive to a slight modification of the ligand structure. The (2-carboxyethyl)phosphinic acid derivative H(5)do3ap(PrA) and the phosphonic acid ligand H(5)do3ap form complexes faster than H(4)dota. The most kinetically inert complex is that with H(4)do3ap(ABn). Rates of complexation and decomplexation can depend on the ability to transfer proton(s) outside/inside the complex cavity and, therefore, on the hydrophobicity of the ligands. The results demonstrate that the new bifunctional ligands are suitable for labelling biomolecules with yttrium(iii) radioisotopes for utilization in nuclear medicine.
Starting Page	1
Ending Page	7
Page Count	7
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.rsc.org/suppdata/dt/b6/b613404a/b613404a.pdf
PubMed reference number	17225905v1
Volume Number	5
Journal	Dalton transactions
Language	English
Access Restriction	Open
Subject Keyword	Acetic Acid Alveolar rhabdomyosarcoma Chemical acidity/alkalinity Dental caries Ions Kinetics Ligands Pendant Dosage Form Peroxisomal Bifunctional Enzyme Phosphinic Acids Phosphorus Propionates Radioisotopes Radionuclide Imaging Thermodynamics Thioctic Acid phosphonic acid
Content Type	Text
Resource Type	Article

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