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Role of the M1 receptor in regulating circadian rhythms.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Gillette, Martha L. U. Buchanan, Gordon F. Artinian, Liana R. Hamilton, Susan E. Nathanson, Neil M. Liu, Chuan |
| Copyright Year | 2001 |
| Abstract | Cholinergic stimuli are potent regulators of the circadian clock in the hypothalamic suprachiasmatic nucleus (SCN). Using a brain slice model, we have found that the SCN clock is subject to muscarinic regulation, a sensitivity expressed only during the night of the clock's 24-h cycle. Pharmacological and signal transduction characteristics are compatible with a response mediated by an M1-like receptor. Molecular manipulation of muscarinic receptors will provide important insights as to the receptor subtype(s) regulating circadian rhythms. |
| Starting Page | 260 |
| Ending Page | 265 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.life.illinois.edu/clockworks/pdfs/2001roleofm1.pdf |
| PubMed reference number | 11392614v1 |
| Volume Number | 68 |
| Issue Number | 22-23 |
| Journal | Life sciences |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Cell Nucleus Circadian Clocks Circadian Rhythms Muscarinic Acetylcholine Receptor Signal Transduction Sleep Disorders, Circadian Rhythm Structure of suprachiasmatic nucleus |
| Content Type | Text |
| Resource Type | Article |