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Oxidative stress in pre-eclampsia; have we been looking in the wrong place?
| Content Provider | Semantic Scholar |
|---|---|
| Author | Williamson, Rachel D. McCarthy, Cathal Michael McCarthy, Fergus P. Kenny, Louise C. |
| Copyright Year | 2017 |
| Abstract | Pre-eclampsia is a disorder of late pregnancy. It is a major cause of maternal and perinatal morbidity and mortality, accounting for nearly 18% of all maternal deaths worldwide; an estimated 77,000 maternal deaths per year [1]. Poor placentation is considered to be an initial cause of the placental ischemia [2]. Placental ischemia in turn gives rise to oxidative stress in the placenta and leads to shedding of syncytiotrophoblast debris into the maternal circulation provoking a systemic maternal inflammatory response and release of sFLT and sENG causing maternal vascular endothelial dysfunction. The ubiquitous nature of the maternal vascular endothelium accounts for the diverse multi-system nature of pre-eclampsia. Currently there is no treatment for pre-eclampsia except delivery of the placenta and the baby, with the attendant risk of iatrogenic prematurity and significant neonatal morbidity and mortality. As a result, intensive research endeavours have focused on defining the molecular mechanisms of pre-eclampsia and the identification of new pre-symptomatic biomarkers of the condition. This review focuses on the role of elevated oxidative stress in the pathology of pre-eclampsia and potential therapeutic agents targeting oxidative stress that may prevent or ameliorate this disorder. |
| Starting Page | 1 |
| Ending Page | 5 |
| Page Count | 5 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/j.preghy.2017.01.004 |
| PubMed reference number | 28501272 |
| Journal | Medline |
| Volume Number | 8 |
| Alternate Webpage(s) | https://cora.ucc.ie/bitstream/handle/10468/5202/KennyOxidative.pdf?isAllowed=y&sequence=1 |
| Alternate Webpage(s) | https://doi.org/10.1016/j.preghy.2017.01.004 |
| Journal | Pregnancy hypertension |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
