Metal-ligand Catalyzed Heterocyclization of Allenic Alcohols

Content Provider	Semantic Scholar
Author	Brzozowska, Aleksandra Sklyaruk, Jan Azofra, Luis Miguel Jang, Youngkyoon Zubar, Viktoriia Cavallo, Luigi Sepelgy, Osama El Rueping, Magnus
Copyright Year	2019
Abstract	In my poster I will present the first example of an iron cyclopentadienone complexcatalysed cycloisomerization of substituted allenes leading to the formation of a new carbon–oxygen bond. Notably, readily available allenic alcohols could be smoothly transformed into unsaturated heterocycles, which are important building blocks for the synthesis of bioactive molecules and natural products. Combined experimental and computational studies show that the iron complex exhibits a dual catalytic role in substrate activation, when the non-innocent cyclopentadienone ligand acts as proton shuttle in the isomerization and demetallation steps. Molecular orbital analysis provides insight into that unexpected and selective heterocyclization reaction.
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://esoc2019.abstracts.eu/0a5376ed4ea84896b3d42c86cd290141.pdf
Alternate Webpage(s)	https://esoc2019.abstracts.eu/MFp1ZXlVNkdlaE5zcTdPdC93OVJBcVhUQjhtWWE5RXJDT2tzSHVqTlBUST0=.pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article