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Neurobehavioral aspects of developmental toxicity testing.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Ulbrich, Beate Palmer, Andrea |
| Copyright Year | 1996 |
| Abstract | Tests for detection of neurobehavioral changes in the offspring have been a regulatory requirement in developmental toxicity testing of drugs for almost 20 years. Keeping their purpose of hazard identification and risk assessment for humans in mind, investigators and agency reviewers have become deeply ingrained with some stereotyped behaviors with respect to such relevant issues as choice of animal species and data evaluation. Other problematic areas of study design and conduct, selection of litter representatives for testing, what methods to combine in a testing battery, and statistical treatment of results and their interpretation, will need more research and discussion in the future. |
| Starting Page | 407 |
| Ending Page | 412 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| PubMed reference number | 9182049v1 |
| Volume Number | 104 |
| Journal | Environmental health perspectives |
| Alternate Webpage(s) | http://citeseerx.ist.psu.edu/viewdoc/download;jsessionid=3AA58F517C15AF14C5582A5417AB27A4?doi=10.1.1.276.5952&rep=rep1&type=pdf |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Adverse reaction to drug Stereotyped Behavior Stereotyping |
| Content Type | Text |
| Resource Type | Article |