Synthesis of 131 I Labeled Quercetin through Oxidation Method Using Chloramine-T for Cancer Radiopharmaceuticals

Content Provider	Semantic Scholar
Author	Sriyani, Maula Eka Utami, Dian Ayu Dwike, Mega Susilo Widyasari, Eva Maria Marzuki, Muharram Sugiharti, Rizky Juwita Nuraeni, Witri
Copyright Year	2019
Abstract	Quercetin is one of the flavonoid groups with antioxidant activity. The objective of this study was to achieve the labeled compound of 131 I-quercetin as a radiotracer for diagnosis and cancer therapy with high labeling efficiency and radiochemical purity. The labeling procedure was conducted by the oxidation reaction using chloramine-T. The effect of pH, reaction time, amount of oxidizing agent and ligand were evaluated in this research. Quercetin was successfully labeled with iodine-131 at pH 11 at room temperature for 10 min mixed in 1000 rpm with the amount of quercetin and chloramine-T is 0.4 and 0.3 mg, respectively. The results demonstrated that the ratio of quercetin/Na 131 I was 2 × 10 5 . The 131 I-quercetin labeling efficiency was 92.03 ± 2.20%, and radiochemical purity of 131 I-quercetin was 99.34 ± 0.58%. The results showed that 131 I-quercetin could be a radiotracer candidate for diagnosis and cancer therapy.
Starting Page	841
Ending Page	848
Page Count	8
File Format	PDF HTM / HTML
DOI	10.22146/ijc.34512
Volume Number	19
Alternate Webpage(s)	https://jurnal.ugm.ac.id/ijc/article/download/34512/23912
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article