NDLI: 5-Hydroxytryptamine modulation of rat parotid salivary gland secretion.

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5-Hydroxytryptamine modulation of rat parotid salivary gland secretion.

Content Provider	Semantic Scholar
Author	Chernick, Warren S. Bobyock, E. Bradford, Patricia A.
Copyright Year	1989
Abstract	5-Hydroxytryptamine (5-HT) has been reported to produce significant responses in blowfly salivary glands, but little information is available concerning its action on mammalian salivary glands. When 5-HT (0.1 mumol/L to 10 mumol/L) is infused i.a. into anesthetized rats, no salivary secretion is obtained from either parotid or submandibular glands. However, when 5-HT is infused along with a threshold concentration of acetylcholine (0.1 mmol/L), potentiation of parotid secretory response is seen with 5-HT (1 mumol/L, 260% increase; 10 mumol/L, 146% increase). Substance P (0.3 mumol/L) combined with 5-HT (1 mumol/L) also resulted in a potentiation of parotid secretion (160% increase). Protein and calcium concentrations were not altered during such treatments. No potentiation of submandibular secretion was noted. Experiments in vitro with parotid cell aggregates exhibited no potentiation associated with the combined use of 5-HT and carbachol, as measured by amylase secretion and inositol trisphosphate accumulation. The experiments indicate that 5-HT substantially modulates parotid salivary secretion in vivo; however, the in vitro findings suggest that 5-HT does not act directly on surface glandular receptors. The magnitude of the in vivo potentiation could very well implicate circulating or released 5-HT as a physiological modulator of endogenous neurotransmitter action.
Starting Page	59
Ending Page	63
Page Count	5
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://jdr.sagepub.com/content/68/1/59.full.pdf
PubMed reference number	2463296v1
Volume Number	68
Issue Number	1
Journal	Journal of dental research
Language	English
Access Restriction	Open
Subject Keyword	Acetylcholine Amylases CDP-Diacylglycerol-Inositol 3-Phosphatidyltransferase Calcium Carbachol Cell secretion Inositol Mammals Modulator Device Component Neurotransmitters Parotid Gland Salivary Glands Serotonin Submandibular gland chemosensitization/potentiation millimole secretion of saliva
Content Type	Text
Resource Type	Article

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