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ELISA-quantitation of phosphorylated tau protein in the Alzheimer's disease brain.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Herrmann, Martin Golombowski, Sidonie Kräuchi, Kurt Frey, Peter Mourton-Gilles, Chantal Hulette, Christine Rosenberg, Christian Mueller-Spahn, Franz Hock, C. |
| Copyright Year | 1999 |
| Abstract | A reliable, sensitive and specific sandwich ELISA for the quantitation of paired helical filament (PHF) tau in human brain was developed using well-defined monoclonal antibodies. We examined rapid-autopsy-derived brain tissue from 21 neuropathologically confirmed Alzheimer's disease (AD) patients and 14 nondemented controls, matched for age, sex and postmortem delay times. We demonstrated significant elevations of phosphorylated tau levels in the frontal and parietal cortex as well as in the hippocampus of AD patients as compared to the nondemented controls. No difference was observed in the cerebellum. Phosphorylated tau levels measured by ELISA were significantly correlated with the presence or absence of neurofibrillary tangles. |
| Starting Page | 2552 |
| Ending Page | 2557 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.chronobiology.ch/wp-content/uploads/publications/1999_04.pdf |
| PubMed reference number | 10567816v1 |
| Volume Number | 42 |
| Issue Number | 4 |
| Journal | European neurology |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Alzheimer's Disease Autopsy Cerebellum Cerebral cortex Cytoskeletal Filaments Enzyme-Linked Immunosorbent Assay Neurofibrillary degeneration (morphologic abnormality) Patients Phosphorylated Tau Protein Measurement Quantitation paired helical filament |
| Content Type | Text |
| Resource Type | Article |
