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A predictive and feedback control algorithm maintains a constant glucose concentration in fed-batch fermentations.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Kleman, Gary L. Chalmers, Jeffrey J. Luli, Gregory W. Strohl, William R. |
| Copyright Year | 1991 |
| Abstract | A combined predictive and feedback control algorithm based on measurements of the concentration of glucose on-line has been developed to control fed-batch fermentations of Escherichia coli. The predictive control algorithm was based on the on-line calculation of glucose demand by the culture and plotting a linear regression to the next datum point to obtain a predicted glucose demand. This provided a predictive "coarse" control for the glucose-based nutrient feed. A direct feedback control using a proportional controller, based on glucose measurements every 2 min, fine-tuned the feed rate. These combined control schemes were used to maintain glucose concentrations in fed-batch fermentations as tight as 0.49 +/- 0.04 g/liter during growth of E. coli to high cell densities. |
| File Format | PDF HTM / HTML |
| DOI | 10.1128/aem.57.4.910-917.1991 |
| Alternate Webpage(s) | http://aem.asm.org/content/57/4/910.full.pdf |
| PubMed reference number | 2059049 |
| Alternate Webpage(s) | https://doi.org/10.1128/aem.57.4.910-917.1991 |
| Journal | Medline |
| Volume Number | 57 |
| Issue Number | 4 |
| Journal | Applied and environmental microbiology |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
