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Ischemic preconditioning and nicotinamide in spinal cord protection in an experimental model of transient aortic occlusion.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Isbir, Cemil Selim Ak, Koray Kurtkaya, Ozlem Zeybek, Umit Akgün, Serdar Scheitauer, Bernd W. Sav, Aydin Cobanoglu, Adnan M. |
| Copyright Year | 2003 |
| Abstract | OBJECTIVES Spinal cord injury is a devastating complication after aortic surgery. The aim of the present study is to examine the effects of ischemic preconditioning (IPC) and nicotinamide containing perfusate in transient aortic occlusion in the rat. METHODS Thirty-two male Spraque-Dawley rats under general anesthesia were randomly assigned to four groups (n=8 in each group). The infrarenal aortas were clamped for 45 min. Groups were as follows: Group 1, undergoing occlusion but receiving no treatment. Group 2, had 5 min of IPC before occlusion. Group 3, received nicotinamide (0.2 ml/l) during the transient occlusion. Group 4, received combined IPC (5 min) and nicotinamide infusion during the transient occlusion. The rats were then allowed for recovery and were tested for their neurological status. All animals were sacrificed at the end of the 48 h and spinal cords also examined histologically. Anti- poly (ADP-ribose) polymerase p85 fragment pAb was used as an immunohistochemical marker for detection of apoptosis. RESULTS In 24 h paraplegia represented as grade 0 and 1 occurred in six animals in Group 1 and two animals in Groups 2 and 3 and one in Group 4. In 48 h six animals in Group 1 and only one animal in Groups 2 and 3 showed a paraplegia. The incidence of neurologic deficit was significantly reduced in animals who had IPC and nicotinamide infusion (P<0.05). At 48 h, combined IPC and nicotinamide showed a significant benefit compared to nicotinamide but not to the IPC alone. Histologic examination of the spinal cords revealed that a neuronal necrosis contributes to acute spinal cord degeneration after a period of aortic occlusion and both nicotinamide and IPC have protective effects against neuronal necrosis. No difference was found among the groups. CONCLUSIONS Both IPC and nicotinamide are beneficial in protection against neurological damage in transient aortic occlusion. IPC alone as expected is significantly beneficial both at 24 and 48 h compared to controls. At 24 h combined nicotinamide and IPC show significant benefit compared to only nicotinamide, but this difference is not maintained at 48 h. |
| Starting Page | 549 |
| Ending Page | 552 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://watermark.silverchair.com/23-6-1028.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAd8wggHbBgkqhkiG9w0BBwagggHMMIIByAIBADCCAcEGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMAV0wCKMFHUOECklVAgEQgIIBkj6ADyT7LchIpCbRoVda7y2Proy4HsLbUy08yhnc7fQb8Zumy217QRzVcw_byN-BqP0wqcCwd2TeU3Hkq3CfyH0CFGc82Q7wiWI6LzoRXIA958S4u-wGPDm11ey6ww2fUgZvozR4V4KmLUagMnE_UqL42-sw1gMeHPBwQ2JeP4fmQwAGhjuj7CB4HiYhO5fTZDflcBqJOp39tqChiJQFwfm_i1gpEPE_jLSOOvNmsr36ARXIXEBpf8_ZdsQniTQdZ_MPzKoKZFjf-LUO1WlIt7GxfR4ZLPtCOEYXsRVx2xpE3Y8DkcE-DuCaPU02p8m58O75F-MeG7Y5i33BYeftZcrI_46rajEkX2gtSp5CeBqsDJ27WRGhIkrqAw5ytvbrAQBWOG0I5SEz__1-HHw1DuZnc-V1ZIRoW_YRSzI93Ff0yre0WmIziWZaCaG5OpT6Fcj18pYYBRTotCeedmhOWPThiQCwTDPOFNsY9ydhjBhafgglPD6V4JrX7-LImC8h8BLdh4g5Y69W5lZ0keOT7N_5Kw |
| Alternate Webpage(s) | https://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/ejcts/23/6/10.1016/S1010-7940(03)00110-6/2/23-6-1028.pdf?Expires=1492060714&Key-Pair-Id=APKAIUCZBIA4LVPAVW3Q&Signature=KNJGdz3WIKhcpWT63a5IPUzq~i6fRWNeOjdHVpB3fspwkF6FR~WfJl0pKGsnJ1-MwBbFki2YcxGmwx2oQ2Yv9erNst-0SWDBiO1uV0d42WUN1GexDCO0DpqS3gNVc7T72DD12ZgB8DvR30A7LcTEKSiI3SOfo5yrJRtcB0KiYQvRrjgBmnQXJu~nwl1JSQfHsOynGDbKrEe~2rlFFXSvEj0SygFXw8qMlSJiuYCfGjR3UZbwQ5Vo8317Rwxw5Xc0yMlLSWHvSci7HcRYc9-TpdbJJD-dYthLeIuDDRhqzrxcAvBmJZN3HGVPxHlzkHwKEKbXTiFfQ622X0GuBbD7mw__ |
| PubMed reference number | 12829083v1 |
| Volume Number | 23 |
| Issue Number | 6 |
| Journal | European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Acute Kidney Tubular Necrosis Adenosine Diphosphate Aorta Apoptosis Ischemic Preconditioning Neurodegenerative Disorders Niacinamide Paraplegia PersonNameUse - assigned Poly A Ribose Spinal Cord Neoplasms Trauma, Nervous System aortic occlusion |
| Content Type | Text |
| Resource Type | Article |
