Diabetes in Pregnancy and MicroRNAs: Promises and Limitations in Their Clinical Application

Content Provider	Semantic Scholar
Author	Ibarra, Adriana Barahona Vega-Guedes, Begoña Brito-Casillas, Yeray Wägner, Ana M.
Copyright Year	2018
Abstract	Maternal diabetes is associated with an increased risk of complications for the mother and her offspring. The latter have an increased risk of foetal macrosomia, hypoglycaemia, respiratory distress syndrome, preterm delivery, malformations and mortality but also of life-long development of obesity and diabetes. Epigenetics have been proposed as an explanation for this long-term risk, and microRNAs (miRNAs) may play a role, both in short- and long-term outcomes. Gestation is associated with increasing maternal insulin resistance, as well as β-cell expansion, to account for the increased insulin needs and studies performed in pregnant rats support a role of miRNAs in this expansion. Furthermore, several miRNAs are involved in pancreatic embryonic development. On the other hand, maternal diabetes is associated with changes in miRNA both in maternal and in foetal tissues. This review aims to summarise the existing knowledge on miRNAs in gestational and pre-gestational diabetes, both as diagnostic biomarkers and as mechanistic players, in the development of gestational diabetes itself and also of short- and long-term complications for the mother and her offspring.
Starting Page	899
Ending Page	904
Page Count	6
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://res.mdpi.com/ncrna/ncrna-04-00032/article_deploy/ncrna-04-00032.pdf?attachment=1&filename=
PubMed reference number	30424584v1
Alternate Webpage(s)	https://doi.org/10.3390/ncrna4040032
DOI	10.3390/ncrna4040032
Journal	Non-coding RNA
Volume Number	4
Language	English
Access Restriction	Open
Subject Keyword	Biological Markers Body tissue Central Diabetes Insipidus Chromosome 3 Short Arm Conflict (Psychology) Congenital Abnormality Diabetes Mellitus, Insulin-Dependent Diabetic Nephropathy Diabetic Neuropathies EBV-BART10-3p microRNA Embryonic Development Gestational Diabetes Heart Diseases Hyperinsulinism Hypoglycemia In Vitro [Publication Type] Insulin Resistance MIR17 wt Allele MIRN9 microRNA, human Maxillary right first premolar prosthesis MicroRNAs Obesity Pancreas Pregnancy in Diabetics Respiratory Distress Syndrome, Adult non-T, non-B childhood acute lymphoblastic leukemia study of epigenetics
Content Type	Text
Resource Type	Article