A Fluorinated Ligand Enables Room-Temperature and Regioselective Pd-Catalyzed Fluorination of Aryl Triflates and Bromides

Content Provider	Semantic Scholar
Author	Sather, Aaron C. Lee, Geun Rosa, Valentina Y. De La Yang, Yang Müller, Peter Buchwald, Stephen L.
Copyright Year	2015
Abstract	A new biaryl monophosphine ligand (AlPhos, L1) allows for the room-temperature Pd-catalyzed fluorination of a variety of activated (hetero)aryl triflates. Furthermore, aryl triflates and bromides that are prone to give mixtures of regioisomeric aryl fluorides with Pd-catalysis can now be converted to the desired aryl fluorides with high regioselectivity. Analysis of the solid-state structures of several Pd(II) complexes, as well as density functional theory (DFT) calculations, shed light on the origin of the enhanced reactivity observed with L1.
Starting Page	13433
Ending Page	13438
Page Count	6
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://web.mit.edu/pmueller/www/own_papers/sather_etal_2015.pdf
PubMed reference number	26413908
Alternate Webpage(s)	https://doi.org/10.1021/jacs.5b09308
DOI	10.1021/jacs.5b09308
Journal	Journal of the American Chemical Society
Volume Number	137
Language	English
Access Restriction	Open
Subject Keyword	Aryl Hydrocarbon Hydroxylases Bromides Catalysis Fluorides Ligands Palladium Parkinson Disease arylsulfatase activity mixture
Content Type	Text
Resource Type	Article