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Downregulation of miR-505 promotes cell proliferation, migration and invasion, and predicts poor prognosis in breast cancer.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Wang, Jing Liu, Haibo Li, Minghong |
| Copyright Year | 2019 |
| Abstract | microRNAs are involved in the tumor progression of various cancer types. The present study aimed to determine the prognostic significance of microRNA-505 (miR-505) in patients with breast cancer and investigate the functional role of miR-505 in BCa progression. The expression of miR-505 was estimated using reverse transcription-quantitative polymerase chain reaction. Kaplan-Meier survival curves and Cox regression analysis were used to evaluate the prognostic value of miR-505 in patients with BCa. Cell experiments were performed to assess the biological function of miR-505 during BCa progression. A significant downregulated expression level of miR-505 was observed in BCa tissues and cells compared with the corresponding controls (P<0.001). The expression of miR-505 was significantly associated with distant metastasis status (P=0.013) and Tumor-Node-Metastasis staging (P=0.002). Furthermore, the overall survival time was significantly shorter for patients with low miR-505 expression compared with those with high miR-505 expression (P<0.001). In addition, miR-505 was identified as an independent prognostic factor for BCa. The results of cell experiments revealed that an overexpression of miR-505 could significantly inhibit BCa cell proliferation, migration and invasion, whereas a downregulation of miR-505 significantly enhanced BCa cell proliferation, migration and invasion (P<0.05). In summary, all data indicated that a low miR-505 expression level is associated with a poor prognosis for patients with BCa and promotes tumor cell proliferation, migration and invasion. Therefore, the aberrant expression of miR-505 may serve as a therapeutic target for BCa. |
| Starting Page | 247 |
| Ending Page | 254 |
| Page Count | 8 |
| File Format | PDF HTM / HTML |
| DOI | 10.3892/ol.2019.10334 |
| PubMed reference number | 31289494 |
| Journal | Medline |
| Volume Number | 18 |
| Issue Number | 1 |
| Alternate Webpage(s) | https://www.spandidos-publications.com/ol/18/1/247/download |
| Alternate Webpage(s) | https://www.spandidos-publications.com/10.3892/ol.2019.10334/download |
| Alternate Webpage(s) | https://doi.org/10.3892/ol.2019.10334 |
| Journal | Oncology letters |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
