NDLI: Anti-inflammatory effects of grape seed procyanidin B 2 on diabetic pancreas

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Anti-inflammatory effects of grape seed procyanidin B 2 on diabetic pancreas

Content Provider	Semantic Scholar
Author	Yin, Wenbin Li, Baoying Li, Xiaoli Cai, Qian Zhang, Zhen Cheng, Mei Gao, Haiqing
Copyright Year	2015
Abstract	Prevalence of type 2 diabetes mellitus (T2DM) has increased considerably in the recent years, highlights the importance of developing new therapeutic strategies. Insulin-resistance and gradual dysfunction of pancreatic islets is the mainstay in the progression of T2DM. Therefore, preserving the function of pancreas may lead to new prospective approaches. Our previous studies suggested that grape seed procyanidin B2 (GSPB2), a natural polyphenol product, exhibited protective effects on diabetic vasculopathy. However, effects of GSPB2 on diabetic pancreas remain unknown. In this study, we provided strong evidence that GSPB2 exerted protective effects on diabetic pancreas. GSPB2 attenuated the elevated body weights, food intake and advanced glycation end-products (AGEs) levels in db/db mice (p < 0.05), though had no significant effects on glucose levels. The increased islet sizes, insulin levels, as well as HOMA-IR, were also improved by GSPB2 treatment in db/db mice (p < 0.05). Milk fat globule epidermal growth factor-8 (MFG-E8), an estimated target of GSPB2 in our previous studies, was up regulated in pancreatic tissues whereas GSPB2 treatment down-regulated its protein level (p < 0.05). Since MFG-E8 is highly involved in inflammation, we further investigate pro-inflammatory cytokines interleukin-1β (IL-1β) and NLRP3 levels. We found that protein levels of IL-1β and NLRP3 increased in diabetic pancreas while GSPB2 treatment notably attenuated these alterations (p < 0.05). In conclusion, our results suggest that inflammation is involved in the damage of diabetic pancreas and GSPB2 provides protective effects at least in part through anti-inflammation. Correspondence to: Haiqing Gao (qilughq@163.com) and Mei Cheng (qilucm@163.com), Department of Geriatrics, Qilu Hospital of Shandong University, 107 Wenhua Xi Road, Jinan, Shandong Province, 250012, China. Page 1 of 13 Food & Function Fo od & Fu nc tio n A cc ep te d M an us cr ip t
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://pubs.rsc.org/en/content/getauthorversionpdf/C5FO00496A
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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