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Central administration of α-melanocyte-stimulating hormone inhibits corticotropin-releasing factor release in adrenalectomized rats
| Content Provider | Semantic Scholar |
|---|---|
| Author | Tozawa, Fumiko Suda, Toshihiro Dobashi, Izumi Ohmori, Nariko Demura, Hiroshi |
| Copyright Year | 1994 |
| Abstract | To determine if there is a short negative feedback effect of hypothalamic ACTH-related peptides on corticotropin-releasing factor (CRF) release in vivo, we examined the effect of cerebroventricular injection of alpha-melanocyte-stimulating hormone (alpha MSH) on ACTH levels in plasma and the anterior pituitary and CRF levels in the median eminence of the hypothalamus in adrenalectomized or sham-operated rats under pentobarbital anesthesia. alpha MSH did not affect basal ACTH or CRF levels in sham operated rats. However, elevated plasma ACTH levels and CRF levels in the median eminence were decreased by central administration of alpha MSH in adrenalectomized rats. These results suggest that there is a short negative feedback effect of alpha MSH on CRF release and it appears only in the absence of a long negative feedback effect of glucocorticoids. |
| Starting Page | 117 |
| Ending Page | 119 |
| Page Count | 3 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/0304-3940(94)90133-3 |
| PubMed reference number | 7970145 |
| Journal | Medline |
| Volume Number | 174 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/0304394094901333 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/0304394094901333?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/0304-3940%2894%2990133-3 |
| Journal | Neuroscience Letters |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
