Loading...
Please wait, while we are loading the content...
Similar Documents
Associations between plasma C-reactive protein levels and the severities of coronary and aortic atherosclerosis.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Momiyama, Yukihiko Ohmori, Reiko Fayad, Zahi A. Kihara, Teruyoshi Tanaka, Nobukiyo Kato, Ryuichi Taniguchi, Hiroaki Nagata, Masayoshi Nakamura, Haruo Ohsuzu, Fumitaka |
| Copyright Year | 2010 |
| Abstract | AIM Limited correlations between C-reactive protein (CRP) and coronary artery disease (CAD) have been reported. Recently, MRI became a useful tool for non-invasively evaluating atherosclerotic plaques in thoracic and abdominal aortas. METHODS To elucidate the associations between plasma CRP levels and the severities of coronary and aortic atherosclerosis, we performed aortic black-blood MRI in 136 patients undergoing coronary angiography. For each patient, 9 slices of thoracic aorta and 9 slices of abdominal aorta were obtained at 12-mm intervals, and the plaque extent in each slice was scored. The degree of aortic atherosclerosis is represented as the sum of scores. The degree of coronary atherosclerosis is represented as the number of >50% stenotic vessels and >25% stenotic segments. RESULTS CAD (>50% stenosis) was present in 96 patients. Patients with CAD had higher CRP levels than those without CAD (median 0.78 vs. 0.48 mg/L, p<0.02). CRP levels tended to increase depending on the number of stenotic vessels: 0.48, 0.70, 0.74, and 0.88 mg/L (p=NS). CRP correlated weakly with the number of stenotic segments (r=0.21). Regarding aortic atherosclerosis, 136 patients were divided into quartiles by plaque score. CRP levels increased stepwise in quartiles: 0.40, 0.56, 1.08, and 1.10 mg/L (p<0.001). CRP levels also correlated with the plaque score (r=0.38). In multivariate analysis, aortic atherosclerosis was an independent factor for CRP levels, but coronary atherosclerosis was not. CONCLUSION Plasma CRP levels correlated with the severities of both coronary and aortic atherosclerosis, but CRP levels are more likely to reflect the severity of aortic atherosclerosis than coronary atherosclerosis. |
| Starting Page | 324 |
| Ending Page | 326 |
| Page Count | 3 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://www.jstage.jst.go.jp/article/jat/17/5/17_2931/_pdf/-char/en |
| PubMed reference number | 20134100v1 |
| Volume Number | 17 |
| Issue Number | 5 |
| Journal | Journal of atherosclerosis and thrombosis |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Abdominal aorta structure Arteriopathic disease Atherosclerosis of aorta Blood Vessel C-reactive protein Chest Coronary Arteriosclerosis Coronary Artery Disease Coronary angiography Dental Plaque Mental association Obstructive Ureterocele Patients Plaque, Atherosclerotic Score Senile Plaques Stenosis Thoracic aorta angiogram |
| Content Type | Text |
| Resource Type | Article |
