NDLI: Short stereoselective synthesis of the Phytophthora universal mating hormone α1 using lithiation/borylation reactions.

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Short stereoselective synthesis of the Phytophthora universal mating hormone α1 using lithiation/borylation reactions.

Content Provider	Semantic Scholar
Author	Pulis, Alexander P. Fackler, Philipp Aggarwal, Varinder K.
Copyright Year	2014
Abstract	The universal mating hormone α 1 of the virulent plant pathogen Phytophthora has been synthesized in 12 steps and 28 % overall yield. Key CC bond-forming steps involved the use of two lithiation/borylation reactions to couple together enantioenriched building blocks, one of which also set up the stereochemistry of the tertiary alcohol at C11. Detailed analysis showed that the diastereomeric purity of the target molecule was >91 %, the highest obtained to date.
File Format	PDF HTM / HTML
DOI	10.1002/anie.201400714
PubMed reference number	24634275
Journal	Medline
Volume Number	53
Issue Number	17
Alternate Webpage(s)	http://research-information.bristol.ac.uk/files/32552204/APulis_ACIE_2014.pdf
Alternate Webpage(s)	https://core.ac.uk/download/pdf/29027096.pdf
Alternate Webpage(s)	http://www.bristol.ac.uk/media-library/sites/chemistry/migrated/documents/223pub.pdf
Alternate Webpage(s)	https://research-information.bristol.ac.uk/files/32552204/APulis_ACIE_2014.pdf
Alternate Webpage(s)	https://doi.org/10.1002/anie.201400714
Journal	Angewandte Chemie
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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