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Bis[(2,2-dimethylpropanoyloxy)methyl] {[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}phosphonate–succinic acid (2/1)
| Content Provider | Semantic Scholar |
|---|---|
| Author | Jung, Sungyup Ha, Jeong-Myeong |
| Copyright Year | 2012 |
| Abstract | The title compound, C(20)H(32)N(5)O(8)P·0.5C(4)H(6)O(4), is composed of two 9-{2-[bis-(pivaloyloxymeth-oxy)phosphinylmeth-oxy]eth-yl}adenine, commonly known as adefovir dipivoxil (AD), mol-ecules linked to the carb-oxy-lic acid groups of succinic acid (SA). The asymmetric unit contains one mol-ecule of AD and half a mol-ecule of SA, which sits on an inversion center. Both adenine units in the two AD mol-ecules make AD-SA N-H⋯O and SA-AD O-H⋯N hydrogen bonds to SA. In addition, the inter-molecular AD-AD N-H⋯O-P hydrogen bond serves to stabilize the cocrystal. There is also a π-π stacking inter-action [inter-planar spacing 3.34 (19) Å] between adjacent inversion-related adenine groups. |
| Starting Page | o809 |
| Ending Page | o810 |
| Page Count | 2 |
| File Format | PDF HTM / HTML |
| DOI | 10.1107/S1600536812006873 |
| PubMed reference number | 22412675 |
| Journal | Medline |
| Volume Number | 68 |
| Alternate Webpage(s) | http://ftp.ncbi.nlm.nih.gov/pub/pmc/05/44/e-68-0o809.PMC3297872.pdf |
| Alternate Webpage(s) | http://journals.iucr.org/e/issues/2012/03/00/pk2386/pk2386.pdf |
| Alternate Webpage(s) | https://doi.org/10.1107/S1600536812006873 |
| Journal | Acta crystallographica. Section E, Structure reports online |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
